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The potential of hard x-rays in view of penetration, spatial resolution, contrast, and compatibility with environmental conditions was for long time locked up by the lack of suitable in x-ray optics.

Wann?

18. Juli 2025, 14:00-15:30

Wo?

ZKS-Uhrturmhörsaal
S2|08, Raum 171
Hochschulstraße 4
64289 Darmstadt

ZKS-Uhrturmhörsaal , S2|08, Raum 171 , Hochschulstraße 4 , 64289 Darmstadt

Veranstalter

Fachbereich Physik

With the advent of highly brilliant radiation, and the development of lens-less diffractive imaging and coherent focusing, the situation has changed. We now have nano-focused coherent x-ray synchrotron beams at hand to probe soft and biological matter as well as materials and nanostructures, both in scanning and in full field imaging and tomography. Source coherence, optics and detection schemes allow to radically rethink our experimental designs. This opens up a plethora of contrast mechanisms, increased resolution, and scalable volume throughput, and automated feature extraction.

In this talk, I will concentrate on the central challenge of inverting the coherent diffraction pattern by suitable reconstruction algorithms in the optical far and near-field [1,2]. I will address optimized experimental design, including illumination with filtered wavefronts based on waveguide optics [1,2], and show how imaging and diffraction can be combined to achieve super-resolution [3].

Finally, different examples of biophysical and biomedical applications will be presented, including whole organ imaging [4], and mappings of human brain tissue [5,6].

References

[1] T. Salditt, A. Egner and R. D. Luke. Nanoscale Photonic Imaging Springer Nature Topics in Applied Physics 134, Open Access Book (2020).

[2] L. M. Lohse, A.-L. Robisch, M. Töpperwien, S. Maretzke, M. Krenkel, J. Hagemann and T. Salditt. A phase-retrieval toolbox for X-ray holography and tomography Journal of Synchrotron Radiation 27, 3 (2020); J. Lucht, P. Meyer, L.M. Lohse, T. Salditt. HoToPy: A toolbox for X-ray holo-tomography in Python- arXiv preprint arXiv:2506.11567

[3] J. Soltau, M. Vassholz, M. Osterhoff and T. Salditt. In-line holography with hard x-rays at sub-15 nm resolution. Optica 8, 823 (2021).

[4] J. Reichmann et al. 3D multiscale characterization of the human placenta: Bridging anatomy and histology by X-ray phase-contrast tomography (2025). PNAS nexus 4 (1), pgae583; J.J. Schaeper et al. Imaging of the human temporal bone by X-ray phase-contrast tomography. npj Imaging 3 (1), 1-11 (2025)

[5] M. Eckermann, B. Schmitzer, F. van der Meer, J. Franz, O. Hansen, C. Stadelmann and T. Salditt. Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography. Proc. Natl. Acad. Sci.

118, 48 (2021).J. Frost et al. 3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis Neuroscience 520, 18 (2023)

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Tags

Physikalisches Kolloquium